RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition
نویسندگان
چکیده
منابع مشابه
RNA کوچک مداخله گر(siRNA)
بیماریهای عفونی ناشی از میکروارگانیسمها همچنان بهعنوان علل عمده مرگ در سراسر جهان مطرح بوده و افزایش تعداد سویههای مقاوم آنها باعث نگرانی زیادی شده است. از زمان کشف خاموشی ژن توسط RNA (RNAi) انقلابی در زمینه کاربرد درمانی آن بهراه افتاده است. استفاده از RNA مداخلهگر پتانسیل درمانی بسیاری برای درمان یا پیشگیری از بیماریها دارد. این RNA ها نقشهای حیاتى در تنظیم رونویسى و پس از رونویسى،...
متن کاملOptimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice
Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics and biodistribution. The PEG chains were conjugated to chemically stabilized siRNA at the 5' termin...
متن کاملComputational and experimental characterization of RNA cubic nanoscaffolds.
The fast-developing field of RNA nanotechnology requires the adoption and development of novel and faster computational approaches to modeling and characterization of RNA-based nano-objects. We report the first application of Elastic Network Modeling (ENM), a structure-based dynamics model, to RNA nanotechnology. With the use of an Anisotropic Network Model (ANM), a type of ENM, we characterize...
متن کاملSize Selective Recognition of siRNA by an RNA Silencing Suppressor
RNA silencing in plants likely exists as a defense mechanism against molecular parasites such as RNA viruses, retrotransposons, and transgenes. As a result, many plant viruses have adapted mechanisms to evade and suppress gene silencing. Tombusviruses express a 19 kDa protein (p19), which has been shown to suppress RNA silencing in vivo and bind silencing-generated and synthetic small interferi...
متن کاملdevelopment and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Functional Materials
سال: 2018
ISSN: 1616-301X,1616-3028
DOI: 10.1002/adfm.201805959